In this paper, a masonry arch is simulated in order to assess both its structural and seismic vulnerability. The non-smooth contact dynamics (NSCD) computational method is used to simulate this type of structure as a collection of bodies under the hypothesis of unilateral constraints and frictional contact, with or without cohesion. Sinusoidal oscillations in three dimensions and real earthquake data have been applied to the supporting base element of the arch model. The primary aim of this study is to better understand the dynamic behaviour of the masonry arch, a typical component of historic unreinforced masonry (URM) structures. This study also assesses the influences of the input parameters on the mechanical and dynamic behaviour of the arch structure. Its collapse mechanism is studied for both cohesive and non-cohesive contact. In addition, we examine the behaviour under seismic loading of the Arles aqueduct, a real historical arched structure located in the south-east of France. Significant information can be obtained from the comparison of the results of advanced numerical analysis, taking into account the precise geometry of the model, the mechanical characteristics of the materials and the observation of the in situ monuments after their collapse.