The role of glioma stem cells in glioma tumorigenesis, Front. Biosci, vol.19, pp.818-824, 2014. ,
Identification of human brain tumour initiating cells, Nature, vol.432, pp.396-401, 2004. ,
Potential biochemical therapy of glioma cancer, Biochem. Biophys. Res. Commun, vol.362, pp.225-229, 2007. ,
Cancer cell invasion: Treatment and monitoring opportunities in nanomedicine, Adv. Drug Deliv. Rev, vol.63, pp.582-596, 2011. ,
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2, J. Biol. Chem, vol.278, pp.4135-4144, 2003. ,
Biological mechanisms of glioma invasion and potential therapeutic targets, J. Neurooncol, vol.53, pp.129-147, 2001. ,
Could nanoparticle systems have a role in the treatment of cerebral gliomas?, Nanomed. Nanotechnol. Biol. Med, vol.7, pp.744-752, 2011. ,
Modulation of glioma cell migration and invasion using Cl(?) and K(+) ion channel blockers, J. Neurosci, vol.19, pp.5942-5954, 1999. ,
Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601), Expert Opin. Drug Deliv, vol.4, pp.175-186, 2007. ,
Contortrostatin, a snake venom disintegrin, induces alphavbeta 3-mediated tyrosine phosphorylation of CAS and FAK in tumor cells, J. Cell. Biochem, vol.79, pp.28-37, 2000. ,
Anti-invasive effect of contortrostatin, a snake venom disintegrin, and TNF-alpha on malignant glioma cells, Anticancer Res, vol.20, pp.4227-4233, 2000. ,
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion, Am. J. Physiol, vol.264, pp.361-369, 1993. ,
Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles, vol.5, pp.256-264, 2009. ,
Tumor paint: A chlorotoxin: Cy5.5 bioconjugate for intraoperative visualization of cancer foci, Cancer Res, vol.67, pp.6882-6888, 2007. ,
Use of chlorotoxin for targeting of primary brain tumors, Cancer Res, vol.58, pp.4871-4879, 1998. ,
Sontheimer, H. Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin, Glia, vol.39, pp.162-173, 2002. ,
Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus, Toxicon, vol.29, pp.1403-1408, 1991. ,
Expression of voltage-activated chloride currents in acute slices of human gliomas, Neuroscience, vol.83, pp.1161-1173, 1998. ,
Properties of voltage-gated chloride channels of the ClC gene family, J. Physiol, vol.482, pp.19-25, 1995. ,
A role for ion channels in glioma cell invasion, Neuron Glia Biol, vol.2, pp.39-49, 2006. ,
Expression of voltage-gated chloride channels in human glioma cells, J. Neurosci, vol.23, pp.5572-5582, 2003. ,
Cell cycle-dependent expression of a glioma-specific chloride current: Proposed link to cytoskeletal changes, Am. J. Physiol, vol.273, pp.1290-1297, 1997. ,
Cl? and K+ channels and their role in primary brain tumour biology, Philos. Trans. R. Soc. Lond. B Biol. Sci, vol.369, 2014. ,
Control of cell proliferation by cell volume alterations in rat C6 glioma cells. Pflügers Arch, Eur. J. Physiol, vol.440, pp.881-888, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-00201162
An unexpected role for ion channels in brain tumor metastasis, Exp. Biol. Med, vol.233, pp.779-791, 2008. ,
Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3, Anticancer Res, vol.30, pp.4515-4524, 2010. ,
Imaging glioma extent with 131I-TM-601, J. Nucl. Med, vol.46, pp.580-586, 2005. ,
Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide, Anticancer Res, vol.30, pp.39-46, 2010. ,
,
Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects, J. Biol. Chem, vol.285, pp.4366-4374, 2009. ,
Knockdown of annexin 2 decreases migration of human glioma cells in vitro, Neuropathol. Appl. Neurobiol, vol.32, pp.271-277, 2006. ,
The role of annexin II in angiogenesis and tumor progression: A potential therapeutic target, Curr. Pharm. Des, vol.13, pp.3568-3575, 2007. ,
Radiation dosimetry of 131I-chlorotoxin for targeted radiotherapy in glioma-bearing mice, J. Neurooncol, vol.71, pp.113-119, 2005. ,
In vivo bio-imaging using chlorotoxin-based conjugates, Curr. Pharm. Des, vol.17, pp.4362-4371, 2011. ,
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy, J. Med. Chem, vol.54, pp.782-787, 2011. ,
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes, Small, vol.4, pp.372-379, 2008. ,
Chlorotoxinmodified macromolecular contrast agent for MRI tumor diagnosis, Biomaterials, vol.32, pp.5177-5186, 2011. ,
Optical and MRI multifunctional nanoprobe for targeting gliomas, Nano Lett, vol.5, pp.1003-1008, 2005. ,
Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier, Cancer Res, vol.69, pp.6200-6207, 2009. ,
Specific targeting of gliomas with multifunctional superparamagnetic iron oxide nanoparticle optical and magnetic resonance imaging contrast agents, Acta Pharmacol. Sin, vol.28, pp.2019-2026, 2007. ,
Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles, Nanomedicine, vol.3, pp.495-505, 2008. ,
Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery, Biomaterials, vol.31, pp.8032-8042, 2010. ,
Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma, J. Clin. Oncol, vol.24, pp.3644-3650, 2006. ,
Development of the research on the application of chlorotoxin in imaging diagnostics and targeted therapies for tumors, Chin. J. Cancer, vol.29, pp.626-630, 2010. ,
Multifunctional Agents, 2013. ,
Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells, J. Inorg. Biochem, vol.110, pp.58-63, 2012. ,
Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O6-Methylguanine-DNA Methyltransferase activity, Biotechnol. Bioeng, vol.110, pp.1211-1220, 2013. ,
Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma, ACS Nano, vol.4, pp.4587-4594, 2010. ,
A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells, Biomaterials, vol.30, pp.649-657, 2009. ,
Targeted delivery of chlorotoxin-modified DNAloaded nanoparticles to glioma via intravenous administration, Biomaterials, vol.32, pp.2399-2406, 2011. ,
Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes, J. Control. Release, vol.152, pp.402-410, 2011. ,
Chlorotoxin fused to IgG-Fc inhibits glioblastoma cell motility via receptor-mediated endocytosis, J. Drug Deliv, p.975763, 2012. ,
Annexin A2 promotes glioma cell invasion and tumor progression, J. Neurosci, vol.31, pp.14346-14360, 2011. ,
Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs, J. Neurooncol, vol.107, pp.457-462, 2012. ,
Targeted diazeniumdiolates: Localized nitric oxide release from glioma-specific peptides and proteins, Int. J. Pharm, vol.422, pp.264-270, 2012. ,
Purification and primary structure of low molecular mass peptides from scorpion ,
, Biochem. Physiol. A. Mol. Integr. Physiol, vol.121, pp.323-332, 1998.
Purification and partial characterization of a "short" insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri, FEBS Lett, vol.441, pp.387-391, 1998. ,
Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus, BMC Biochem, vol.2, p.16, 2001. ,
The gene cloning and sequencing of Bm-12, a Chlorotoxin-like peptide from the scorpion Buthus martensi Karsch, Toxicon, vol.38, pp.661-668, 2000. ,
Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom, Peptides, vol.32, pp.656-663, 2011. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00606677
Cloning and characterization of a cDNA sequence encoding the precursor of a chlorotoxin-like peptide from the Chinese scorpion Buthus martensii Karsch, Toxicon Off. J. Int. Soc. Toxinology, vol.38, pp.1009-1014, 2000. ,
Synthesis, expression and purification of a type of chlorotoxin-like peptide from the scorpion, Buthus martensii Karsch, and its acute toxicity analysis, Biotechnol. Lett, vol.27, pp.1597-1603, 2005. ,
State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin, J. Biol. Chem, vol.282, pp.37545-37555, 2007. ,
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels, J. Biol. Chem, vol.284, pp.26051-26052, 2009. ,
@TOME-2: A new pipeline for comparative modeling of protein-ligand complexes, Nucleic Acids Res, vol.37, pp.485-491, 2009. ,
SWISS-MODEL: Modelling protein tertiary and quaternary structure using evolutionary information, Nucleic Acids Res, p.42, 2014. ,
The SWISS-MODEL repository of annotated three-dimensional protein structure homology models, Nucleic Acids Res, vol.32, pp.230-234, 2004. ,
The SWISS-MODEL workspace: A web-based environment for protein structure homology modelling, Bioinformatics, vol.22, pp.195-201, 2006. ,
The SWISS-MODEL Repository and associated resources, Nucleic Acids Res, vol.37, pp.387-392, 2009. ,
Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective, Electrophoresis, vol.30, 2009. ,
Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro, J. Neurooncol, vol.73, pp.1-7, 2005. ,
An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch, Toxicon, vol.40, pp.1239-1258, 2002. ,
Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas, Neurosci. Lett, vol.412, pp.62-67, 2007. ,
Polyclonal antibody against a recombinant chlorotoxin-like peptide from the Chinese scorpion and detection of its putative receptors in human glioma cells, Biotechnol. Lett, vol.28, pp.1439-1443, 2006. ,
A model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study, Biotechnol. Lett, vol.33, pp.1309-1317, 2011. ,
BmK CT-conjugated fluorescence nanodiamond as potential glioma-targeted imaging and drug, Diam. Relat. Mater, vol.21, pp.73-76, 2012. ,
Anti Tumor Translocation Peptide of Scorpion, Preparation Method and Application, 2007. ,
Characterization of a new family of toxin-like peptides from the venom of the scorpion Leiurus quinquestriatus hebraeus. 1H-NMR structure of leiuropeptide II, J. Pept. Res. Off. J. Am. Pept. Soc, vol.49, pp.545-555, 1997. ,