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Patents
Synthèse peptidique continue, sans solvant et non enzymatique par extrusion réactive
Synthèse peptidique continue, sans solvant et non enzymatique par extrusion réactive
Abstract : The present disclosure relates to A a continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I) :
Ra-POLYPEP-Rc (I)
wherein :
POLYPEP is a poly-amino acid compound,
Ra and Rc are as specified in the disclosure,
which method comprises the steps of:
a) feeding an extrusion reactor with
(1) a compound of formula (II)
Ra-PEPNt-Rg (II)
wherein;
PEPNt is a mono- or a poly-aminoacid compound,
Ra and Rg are as specified in the disclosure,
and
(2) a compound of formula (III)
H-PEPCt-Rc (III)
wherein :
PEPCt is a mono- or a poly-amino acid compound, and
Rc is as defined in the disclosure
in the absence of any solvent,
so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and
b) collecting the compound of formula (I) from the extrusion reactor.
https://hal.mines-ales.fr/hal-02503681
Contributor : Administrateur Imt - Mines Alès Connect in order to contact the contributor
Submitted on : Tuesday, March 10, 2020 - 10:48:10 AM
Last modification on : Wednesday, October 20, 2021 - 1:23:04 AM
Contributor : Administrateur Imt - Mines Alès Connect in order to contact the contributor
Submitted on : Tuesday, March 10, 2020 - 10:48:10 AM
Last modification on : Wednesday, October 20, 2021 - 1:23:04 AM