C2MA - Centre des Matériaux des Mines d'Alès (École des Mines d'Alès / Centre des Matériaux des Mines d'Alès
6 Avenue de Clavières
30319 ALES cedex
Téléphone : +33 4 66 78 50 00
Par courrier électronique : c2ma@mines-ales.fr - France)
IMT - MINES ALES - IMT - MINES ALES (IMT - Mines Ales École des Mines
Site de Clavières : 6 avenue de Clavières, 30319 Alès Cedex
Site de Croupillac : Rue Jules Renard, 30100 Alès
Site de Pau : Hélioparc (bâtiment Einstein 1), 2 avenue du Président-Pierre-Angot, 64053 Pau Cedex 9 - France)
Abstract : The present disclosure relates to A a continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I) :
Ra-POLYPEP-Rc (I)
wherein :
POLYPEP is a poly-amino acid compound,
Ra and Rc are as specified in the disclosure,
which method comprises the steps of:
a) feeding an extrusion reactor with
(1) a compound of formula (II)
Ra-PEPNt-Rg (II)
wherein;
PEPNt is a mono- or a poly-aminoacid compound,
Ra and Rg are as specified in the disclosure,
and
(2) a compound of formula (III)
H-PEPCt-Rc (III)
wherein :
PEPCt is a mono- or a poly-amino acid compound, and
Rc is as defined in the disclosure
in the absence of any solvent,
so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and
b) collecting the compound of formula (I) from the extrusion reactor.
Yves Yeboue, Benjamin Gallard, Nicolas Le Moigne, Frédéric Lamaty, Jean Martinez, et al.. Synthèse peptidique continue, sans solvant et non enzymatique par extrusion réactive. France, Patent n° : EP3527580. 2018. ⟨hal-02503681⟩