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Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Luis Midão Sinthia Bosnic‐anticevich Rojin Rajabian‐soderlund Sylvie Arnavielhe 1 Isabella Annesi‐maesano Josep Antó 2 Govert de Vries Valentina Orlando Désirée Larenas‐linnemann Giulia de Feo 3 Joao Fonseca 4 Mario Morais‐almeida Ana Maria Pereira Ana Maria Todo‐bom Karl Christian Bergmann Ralph Mosges 5 Nikos Papadopoulos Emmanuel Prokopakis Regina Roller‐wirnsberger Peter Valentin Tomazic Alvaro Cruz Wytske Fokkens Jean‐françois Fontaine Sanna Toppila‐salmi Peter Hellings 6 Erik Melen 7 Carsten Bindslev‐jensen Robyn O'Hehir 8 Bilun Gemicioğlu 9 Ömer Kalayci 10 Juan Carlos Ivancevich Jean Bousquet 11 Pw Hellings W Aberer I Agache Ca Akdis M Akdis Mr Aliberti R Almeida F Amat R Angles I Annesi‑maesano Ij Ansotegui Jm Anto ‑ S Arnavielle E Asayag A Asarnoj H Arshad F Avolio E Bacci Claus Bachert 12 I Baiardini C Barbara M Barbagallo I Baroni Ba Barreto X Basagana Ed Bateman M Bedolla‑barajas Anna Bedbrook 13 Mike Bewick B Beghé Eh Bel Kc Bergmann Ks Bennoor M Benson L Bertorello Az Białoszewski T Bieber Slawomir Bialek C Bindslev‑jensen L Bjermer H Blain F Blasi A Blua M Bochenska Marciniak I Bogus‑buczynska Al Boner M Bonini S Bonini Cs Bosnic‑anticevich Isabelle Bosse 14 J Bouchard Lp Boulet R Bourret Pj Bousquet F Braido Vitalis Briedis Ce Brightling J Brozek C Bucca R Buhl R Buonaiuto C Panaitescu Mt Burguete Cabañas E Burte A Bush F Caballero‑fonseca D Caillaud D Caimmi Ma Calderon Pam Camargos T Camuzat G Canfora Gw Canonica Vicky Cardona Kh Carlsen P Carreiro‑martins Am Carriazo W Carr C Cartier T Casale G Castellano Lorenzo Cecchi 15 Am Cepeda Nh Chavannes Y Chen R Chiron T Chivato E Chkhartishvili Ag Chuchalin Kf Chung Mm Ciaravolo A Ciceran Cemal Cingi 16 G Ciprandi Ac Carvalho Coehlo L Colas E Colgan J Coll D Conforti J Correia De Sousa Rm Cortés‑grimaldo F Corti Elísio Costa 17 Mc Costa‑dominguez Al Courbis 18 L Cox M Crescenzo Aa Cruz A Custovic Wienczyslawa Czarlewski 19 Se Dahlen G D’amato C Dario J Da Silva Y Dauvilliers U Darsow F De Blay G De Carlo T Dedeu M de Fátima Emerson G De Feo G De Vries B De Martino Np Motta Rubina D Deleanu P Demoly Ja Denburg Philippe Devillier 20 S Di Capua Ercolano N Di Carluccio A Didier D Dokic Mg Dominguez‑silva H Douagui G Dray 18 R Dubakiene Sr Durham G Du Toit Ms Dykewicz Y El‑gamal P Eklund Esben Eller 21 R Emuzyte J Farrell A Farsi J Ferreira de Mello Jr J Ferrero A Fink‑wagner A Fiocchi Wj Fokkens Ja Fonseca Jf Fontaine S Forti Jm Fuentes‑perez Jl Gálvez‑romero A Gamkrelidze J Garcia‑aymerich Cy García‑cobas Mh Garcia‑cruz B Gemicio Ğ Lu S Genova G Christoff Je Gereda R Gerth Van Wijk Rm Gomez J Gómez‑vera S González Diaz M Gotua I Grisle M Guidacci Na Guldemond Z Gutter Ma Guzmán Tari Haahtela 22 J Hajjam L Hernández Jo’b Hourihane Yr Huerta‑villalobos M Humbert G Iaccarino M. Illario Z Ispayeva Jc Ivancevich Ej Jares E Jassem Sl Johnston G Joos Ks Jung J Just M Jutel I Kaidashev O Kalayci Af Kalyoncu J Karjalainen P Kardas Thomas Keil 23 Pk Keith M Khaitov N Khaltaev J Kleine‑tebbe Ludger Klimek 24 Ml Kowalski M Kuitunen I Kull Piotr Kuna 25 M Kupczyk Violeta Kvedariene 26 E Krzych‑fałta P Lacwik D Larenas‑linnemann Daniel Laune 27 D Lauri J Lavrut Ltt Le M Lessa G Levato J Li P Lieberman A Lipiec B Lipworth Kc Lodrup Carlsen R Louis O Lourenço Ja Luna‑pech A Magnan B Mahboub D Maier Alpana Mair I Majer João Malva 28 E Mandajieva P Manning E de Manuel Keenoy Gd Marshall Mr Masjedi Jf Maspero Jj Matta Campos Al Matos M Maurer S Mavale‑manuel O Mayora Ma Medina‑avalos E Melén E Melo‑gomes Eo Meltzer Enrica Menditto 29 J Mercier N Miculinic F Mihaltan B Milenkovic G Moda Md Mogica‑martinez Y Mohammad I Momas S Montefort R Monti D Mora Bogado M Morais‑almeida Ff Morato‑castro R Mösges A Mota‑pinto P Moura Santo Joaquim Mullol 30 L Münter A Muraro R Murray R Naclerio R Nadif M Nalin L Napoli L Namazova‑baranova H Neffen V Niedeberger K Nekam A Neou A Nieto L Nogueira‑silva M Nogues Ettore Novellino 31 Td Nyembue Re O’hehir C Odzhakova K Ohta Y Okamoto K Okubo Gl Onorato M Ortega Cisneros S Ouedraogo I Pali‑schöll S Palkonen P Panzner Ng Papadopoulos Hs Park A Papi G Passalacqua E Paulino R Pawankar S Pedersen Jl Pépin Am Pereira M Persico Oliver Pfaar 32 J Phillips R Picard B Pigearias I Pin C Pitsios D Plavec W Pohl Ta Popov F Portejoie P Potter Ac Pozzi D Price Ep Prokopakis R Puy B Pugin Re Pulido Ross M Przemecka Kf Rabe F Raciborski R Rajabian‑soderlund Sietze Reitsma I Ribeirinho J Rimmer D Rivero‑yeverino Ja Rizzo Mc Rizzo C Robalo‑cordeiro F Rodenas X Rodo M Rodriguez Gonzalez L Rodriguez‑mañas C Rolland S Rodrigues Valle M Roman Rodriguez A Romano E Rodriguez‑zagal G Rolla Re Roller‑wirnsberger M Romano J Rosado‑pinto N. Rosario M Rottem Dermot Ryan 33 H Sagara J Salimäki Boleslaw Samolinski 34 M Sanchez‑borges J Sastre‑dominguez Gk Scadding Hj Schunemann N Scichilone P Schmid‑grendelmeier Fs Serpa S Shamai Aziz Sheikh 35 M Sierra Fer Simons V Siroux Jc Sisul I Skrindo D Solé D Somekh M Sondermann T Sooronbaev M Sova M Sorensen M Sorlini O Spranger Cristiana Stellato R Stelmach R Stukas J Sunyer – J Strozek A Szylling Jn Tebyriçá M Thibaudon T To A Todo‑bom Pv Tomazic S Toppila‑salmi U Trama M Triggiani C Suppli Ulrik M Urrutia‑pereira R Valenta A Valero Arunas Valiulis 36 E Valovirta M Van Eerd E Van Ganse M Van Hague O Vandenplas Mt Ventura G Vezzani T Vasankari A Vatrella Mt Verissimo F Viart G Viegi D Vicheva T Vontetsianos M Wagenmann S Walker D Wallace Dy Wang S Waserman T Werfel M Westman Magnus Wickman 37 Dm Williams S Williams N Wilson J Wright P Wroczynski P Yakovliev Bp Yawn Pk Yiallouros A Yorgancioglu Om Yusuf Hj Zar L Zhang N Zhong Me Zernotti I Zhanat M Zidarn Torsten Zuberbier 38 C Zubrinich A Zurkuhlen
1 Kyomed
2 CREAL - Center for Research in Environmental Epidemiology
3 UNISA - University of Salerno
4 CINTESIS - Center of Research in Health Technologies and Information Systems
5 Institute of Medical Statistics, Informatics and Epidemiology (IMSIE)
6 Department of Otorhinolaryngology, Head, and Neck Surgery
7 Institute of Environmental Medicine
8 Department of Allergy, Immunology and Respiratory Medicine
9 Cerrahpasa Faculty of Medicine
10 Hacettepe University = Hacettepe Üniversitesi
11 VIMA - Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique
12 Department for Molecular Biomedical Research
13 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
14 CHU Montpellier
15 Università degli Studi di Firenze = University of Florence [Firenze]
16 Department of Otorhinolaryngology, Head and Neck Surgery
17 Universidade do Porto
18 LGI2P - Laboratoire de Génie Informatique et d'Ingénierie de Production
19 UCB Pharma, Colombes
20 LOBIP - Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique
21 Department of Dermatology and Allergy Centre
22 Department of Dermatology
23 Institute of Social Medicine
24 German Society for Otorhinolaryngology HNS
25 MUL - Medical University of Łódź
26 Vilnius University [Vilnius]
27 IRIM - Institut de Recherche en Infectiologie de Montpellier
28 UC - University of Coimbra [Portugal]
29 "Federico II" University of Naples Medical School
30 Transverse group for research in primary care [Barcelona]
31 University of Naples Federico II
32 Department of Otorhinolaryngology, Head and Neck Surgery
33 Allergy and Respiratory Research Group
34 Department of Prevention of Envinronmental Hazards and Allergology
35 Asthma UK Centre for Applied Research [Edinburgh, U.K.]
36 Vilnius University Clinic of Children's Diseases
37 Sachs’ Children and Youth Hospital [Stockholm, Sweden]
38 GA2LEN - Secretary General of the Global Allergy and Asthma European Network
Abstract : Background Mobile technology may help to better understand the adherence to treatment. MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods An observational cross‐sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty‐six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non‐adherent to medications (MPR <70%). Of those, the largest group was non‐adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance Adherence to treatment is low. The relative efficacy of continuous vs on‐demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication‐taking behaviour in a real‐world setting.
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Journal articles
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https://hal.mines-ales.fr/hal-02440649
Contributor : Administrateur Imt - Mines Alès <>
Submitted on : Wednesday, January 15, 2020 - 11:57:25 AM
Last modification on : Wednesday, June 24, 2020 - 4:19:56 PM

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EM-ALES | UVSQ | BS | UNIV-MONTPELLIER | CNRS | UNIV-PARIS-SACLAY | INSTITUT-TELECOM

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Luis Midão, Sinthia Bosnic‐anticevich, Rojin Rajabian‐soderlund, Sylvie Arnavielhe, Isabella Annesi‐maesano, et al.. Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy, Wiley, 2019, 49 (4), pp.442-460. ⟨10.1111/cea.13333⟩. ⟨hal-02440649⟩

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